The Martyrdom of Saint Agatha AD251 under Emperor Decius involved the removal of her breasts. By Sebastiano del Piombo, 1520s
The last and most serious persecution of Christians was a failure
The onset of climate change caused the first brief persecution of Christians from AD250-1 and AD257-60 – after all someone had to take the blame for the drought and disease.

Minne di Sant'Agata, a typical Sicilian sweet shaped as a breast, representing the cut breasts of Saint Agatha
But it was the fact that church leaders were taking roles in government that led to the worst persecution starting in AD303. Emperor Diocletian had worked hard to restore the Roman Empire to its former glory and surrounded himself with the mystical paraphernalia of a religious court. He declared himself the one great pagan god’s greatest servant.
It was Conservative factions at the imperial court, afraid of losing their power to Christians, who persuaded Diocletian to unleash the worst persecution the ancient church ever faced. Its buildings were razed and many of its books destroyed. The Church leadership was hounded, tortured and executed. The persecution continued until AD311 when Emperor Galerius ended the terror and issued an edict of toleration.
The persecution, however, had been a failure and it was to be the last. Christians had apparently become so embedded in local society that there was no appetite to get rid of them. Now there was no going back.
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